Research

This page showcases the main research projects I’ve worked on during my PhD

Epigenetic Memory in T cells

Rose, J.R., Akdogan-Ozdilek, B., Rahmberg, A.R. et al. Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential. Commun Biol 6, 363 (2023).

Link to article

  • Integrated RNA & ATACseq analysis of memory T cells
  • Memory T cells exhibited unique chromatin accessibility regions before and after secondary activation (PARs)
  • PARs helped to distinguish distinct subtypes of memory T cells

Autoimmunity

Rose, J.R., Ishii Y., et al. Clinically inactive SLE resting naïve B cells retain distinct transcriptomes and durable alterations to the epigenome

Manuscript in preparation

  • Multi-omic study of B cells in Systemic Lupis Erythmatosis (SLE) patients

  • Motivating question: Do changes in disease activity affect cellular and molecular phenotypes of B cells in SLE?